Salve a tutti, sono nuovo e mi presento con una segnalazione su un tema a me molto caro, la ricerca medica dedicata all'allungamento non solo delle aspettative di vita media, ma anche di quelle di vita massima, cioe' la cosiddetta life-extension (quanto segue viene dal mio blog, dedicato appunto, fra le altre cose, al "longevismo").

Ciao,
Fabio

Tutte le presentazioni del recente Edmonton Aging Symposium sono ora disponibili online (video e/o audio e presentazioni PowerPoint). Dato che sono in inglese, riporto qui sotto la lista completa in lingua originale. Carino il riassunto, dritto-dritto al punto: damage e therapy. Ne ho seguite solo tre, fino ad ora, quella Bailey (sull'impatto economico-sociale della life-extension), il dibattito Stock - Callahan, e quella di Ashley Bush (su una nuova terapia per l'Alzheimer che funziona sui topi: non perdetevi la dimostrazione con topo-Alzheimer-senza-trattamento e topo-Alzheimer-trattato-con-nuovo-medicinale, verso la fine del video). Quelli che mi sembrano piu' interessanti senza averle viste sono quelle di Judith Campisi, Irina Conboy, Aubrey de Grey (sempre interessante...), dell'italiano Luigi Fontana (sulla restrizione calorica), David Gardiner, Howard Haimes (della Alteon, l'azienda dietro l'alagebrium), Kevin Perrot (sull'Mprize) - ma sono tutte affascinanti! Ulteriori commenti, quando avro' tempo di seguirne altre...

Ronald Bailey - Reason Magazine. Award Winning Journalist and Author Focusing on Future Technologies and the Rights of Individuals

Ashley Bush MD PhD. - Mental Health Research Institute of Victoria. Clearing Your Head with PBT2. Damage: Junk Between Cells - Alzheimer's Plaques. Therapy: Dissolve With Novel Pharmaceutical Agent

Daniel Callahan PhD. - The Hastings Center. Bioethicist Who Questions the Ethics of Developing Anti-Aging Therapies

Judith Campisi PhD. - Buck Institute. Old Bodies, Old Cells. Damage: Cells - Too Many - Senescent Cells. Therapy: Induced Cell Death (Apoptosis)

Irina Conboy PhD. - Bioengineering, UC Berkley. Conservation of Aging Within Stem Cell Niches. Damage: Too Few Cells - Muscle Wasting. Therapy: Continuous Exposure to Young Blood Plasma

Aubrey de Grey PhD. (Cambridge). Biological Theorist Proposes an Engineering Approach to Repairing the Damage of Aging

Tarek El-Bialy PhD. - University of Alberta. Using Ultrasound to Stimulate Bone Growth. Damage: Too Few Cells - Bone and Tooth Loss. Therapy: Ultrasound Induced Bone and Tooth Growth

Janet Fast PhD. - University of Alberta. Hidden Costs/Invisible Contributions: Two Faces of Population Aging

Luigi Fontana MD PhD-Washington University in St. Louis, & Italian National Institute of Health. Is Caloric Restriction the Key to a Longer and Healthier Life? Damage: Many Types. Therapy: Caloric Restriction Shows Attentuation of Biomarkers of Aging

David M Gardiner PhD. - UC Irvine. Regeneration in Vertebrates - Teasing Out the Secrets of Limb Regeneration. Damage: Too Few Cells - All Tissues. Therapy: Induction of Regenerative Pathways

Pierrette Gaudreau PhD - University of Montreal. Nutrition as a Determinant of Successful Aging - The Quebec Longitudinal Study 'NuAge'. Damage: Various. Therapy: Nutrition and Exercise

Geoff Goldspink PhD. - University College London. Understanding regulation of muscle strength and muscle wasting at the gene level. Damage: Too Few Cells - Muscle Wasting. Therapy: Pharmaceutical. Intervention/Gene Therapy with Protein that Induces Muscle Regeneration

Howard Haimes PhD. - Alteon Pharmaceuticals. Hardening of the Arteries - Breaking the Ties that Bind. Damage: Protein X-Links. Therapy: Small Molecule Therapy

Ellen Heber-Katz PhD. - Wistar Institute. Recent Results in the MRL Mouse System. Damage: Too Few Cells - All Tissues. Therapy: Induction of Regenerative Pathways

Russell Hepple PhD. - U of Calgary. Mechanisms by which Caloric Restriction Better Preserves Skeletal Muscle Mass & Function with Aging. Damage: Too Few Cells - Muscle Wasting and Loss of Strength. Therapy: Caloric Restriction

Chris Heward PhD. - Kronos Science Laboratories. The Role of Nutrition and Exercise In Achieving Optimal Health and Longevity. Damage: Various. Therapy: Healthy Living

Jay Jerome PhD. - Vanderbilt University Medical Center. Atherosclerosis and Lysosomal Junk. Damage: Junk - Inside Cells. Therapy: Various

James Joseph PhD. - Tufts University. The Beneficial Effects of Fruits in Brain Aging and Behavior: Putative Effects on Signalling. Damage: Junk Between Cells - Alzheimer Plaques. Therapy: Nutritional Intervention

Konstantin Khrapko PhD. - Harvard Medical. Mitochondrial DNA Mutations and Their Possible Role in Brain Aging. Damage: Mitochondrial DNA Mutations. Therapy: Move DNA Out of Harms Way

Patrick Lee PhD. - Dalhousie University. Viruses as cancer therapy. Damage: DNA Mutations. Therapy: Reovirus mediated cancer cell death

Cynthia Lemere PhD. - Brigham and Women's Hospital/Harvard Medical School. Immunotherapy and Alzheimer's. Damage: Junk Between Cells - Alzheimer Plaques. Therapy: Antibody Induced Clearance

Bernard Lemire PhD. - University of Alberta. Mitochondria - Central Players in Longevity. Damage: Various

Evangelos Michelakis MD - U of A. Small Molecules and Suicide Switches. Damage: Cancer - Various Forms. Therapy: Small Molecule Induction of Apoptosis

Bill Moore-Kilgannon - Public Interest Alberta. Alberta's Seniors Deserve Better

Janko Nikolich-Zugich MD. PhD - Oregon Health & Science. The Aging Immune System - Too Many Clones. Damage: Too Many Cells - Immune System Senescence. Therapy: Tailored Hormone and Vaccine Treatments

Amit Patel PhD. - U of Pittsburgh Medical Center. Adult Stem Cells and Heart Repair. Damage: Cells - Too Few - Heart Disease. Therapy: Adult Stem Cell Therapy with Patient's Own Stem Cells

Kevin Perrott PhD Student – UofA. The Mprize - Fame and Fortune for the Oldest Mouse.

Doros Platika MD. - Pittsburgh Life Sciences Greenhouse. Commercializing Regenerative Medicine and the Supercentenarian Research Foundation

Karl Riabowol PhD. - University of Calgary. Modern Cancer Therapies - Stepping Stones to a Cancer Free Future. Damage: Chromosomal DNA Damage – Cancer. Therapy: Various

Bruce Rittmann PhD. - The Biodesign Institute. Engineering Lysosomal Junk – LysoSENS. Damage: Junk Inside Cells - All Tissues. Therapy: Bioremediation with Lysosome Directed Bacterial Enzymes

Gregory Stock PhD. – UCLA. Alzheimer's Researcher and Advocate of the Development of Healthy Life-Extension Technologies

Laurel Strain PhD. - U of A, Alberta Center on Aging. Myths and Realities of Aging

Hasan Uludag PhD. – UofA. Scaffolds, Growth Factors and Tissue Constructs Damage: Too Few Cells - General Loss. Therapy: Tissue Engineering

Huber Warner PhD. - U of Minnesota. We get older, damage happens, we age, but how are these things related?

Michael West PhD. - Advanced Cell Technology. Embryonic Stem Cells and Nuclear Transfer: The Challenges and Opportunities of Regenerative Medicine. Damage: Too Few Cells - All Tissues. Therapy: Therapeutic Cloning and Tissue Engineering