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Discussione: Kefir ovvero l'Elisir di Lunga Vita

  1. #1
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    Exclamation Kefir ovvero l'Elisir di Lunga Vita

    Diversi studi hanno evidenziato le proprietà miracolose del Kefir, ovvero del latte fermentato per circa 24 ore a temperatura ambiente mediante i grani di Kefir.

    Diversi articoli e sperimentazioni pubblicate su PubMed evidenziano che i batteri e i lieviti contenuti nei grani di Kefir sono in grado in particolare di attivare il sistema immunitario e le cellule killer che in tal modo riescono a neutralizzare più facilmente microrganismi patogeni e cellule tumorali.

    Si ritiene che l'origine di tale composto si probiotici e lieviti che vivono in simbiosi si siano originati grazie dalle usanze dei pastori del Caucaso che erano soliti riporre il latte nello stomaco essiccato delle capre.

    E guarda caso tra tutti gli animali esistenti le capre sono l'unica specie animale nella quale i tumori sono rarissimi.

    "La vera guida dei popoli sono le sue tradizioni. Senza tradizioni, vale a dire senza anima nazionale, non è possibile nessuna civiltà". Gustave Le Bon, Psicologia delle Folle [PDF GRATUITO]

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  2. #2
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    Predefinito Re: Kefir ovvero l'Elisir di Lunga Vita

    1. De Moreno de LeBlanc A, Matar C, LeBlanc N, Perdigon G. Effects of milk fermented by Lactobacillus hel-
    veticus R389 on a murine breast cancer model. Breast Cancer Res 2005; 7(4): R477-86.
    2. De Moreno de Le Blanc A, Chaves S, Carmuega E, Weill R, Antoine J, Perdigon G. Effect of long term con-
    tinuous consumption of fermented milk containing probiotic bacteria on mucosal immunity and the acti-
    vity of peritoneal macrophages. Immunobiology 2008; 213(2): 97-108.
    3. Vinderola G, Matar C, Palacios J, Perdigon G. Mucosal immunomodulation by the non-bacterial fraction of
    milk fermented by Lactobacillus helveticus R389. Int J Food Microbiol 2007; 115(2): 180-6.
    4. De Moreno de LeBlanc, Perdigon G. The application of probiotic fermented milks in cancer and intestinal
    inflammation. Proc Nutr Soc 2010; 69(3): 421-8.
    5. Farnworth ER, Mainville I. Kefir: a fermented milk product, pp: 77-112. In: Farnworth ER (ed), Handbook
    of Fermented Functional Foods. 2003. CRC Press, Florida, USA.
    6. Wagar LE, Champagne CP, Buckley ND, Raymond Y, Gren-Johnson JM. Immunomodulatory properties of
    fermented soy and dairy milks prepared with lactic acid bacteria. J Food Sci 2009; 74(8): 423-30.
    7. Acikgoz ZC, Gamberzade S, Göçer S, Ceylan P. Inhibitor effect of vaginal lactobacilli on group B strepto-
    cocci. Mikrobiyol Bul 2005; 39(1): 17-23.
    8. Hong WS, Chen YP, Chen MJ. The anti-allergic effect of kefir lactobacilli. J Food Sci 2010; 75(8): 244-53.
    9. Vinderola CG, Duarte J, Thangavel D, Perdigon G, Farnworth E, Matar C. Remote-site stimulation and du-
    ration of the immune response by kefir. Eur J Inflamm 2005; 3(2): 63-73.
    10. Shiby VK, Mishra HN. Fermented milks and milk products as functional foods-a review. Crit Rev Food Sci
    Nutr 2013; 53(5): 482-96.
    11. Malago JJ, Tooten PC, Koninkx JF. Anti-inflammatory properties of probiotic bacteria on Salmonella-induced
    IL-8 synthesis in enterocyte-like Caco-2 cells. Benef Microbes 2010; 1(2): 121-30.
    12. Wassenberg J, Nutten S, Audran R, et al. Effect of Lactobacillus paracasei ST11on a nasal provocation test
    with grass polen in allergic rhinitis. Clin Exp Allergy 2011; 41(4): 565-73.
    13. Daig R, Andus T, Aschenbrenner E, Falk W, Schmerich J, Gross V. Increased interleukin 8 expression in the
    colon mucosa of patients with inflammatory bowel disease. Gut 1996; 38(2): 216-22.
    14. Harig JM, Soergel KH, Komorowski RA, Wood CM. Treatment of diversion colitis with short chain fatty acid
    irrigation. N Engl J Med 1989; 320(1): 23-8.
    15. Candela M, Perna F, Carnevali P, et al. Interaction of probiotic Lactobacillus and Bifidobacterium strains with
    human intestinal epithelial cells: adhesion properties, competition against enteropathogens and modulati-
    on of IL-8 production. Int J Food Microbiol 2008; 125(3): 286-92.
    16. Frick JS, Schenk K, Quitadamo M, et al. Lactobacillus fermentum attenuates the proinflammatory effect of
    Yersinia enterocolitica on human epithelial cells. Inflamm Bowel Dis 2007; 13(1): 83-90.
    17. Liu JR, Wang SY, Lin YY, Lin CW. Anti-tumor activity of milk kefir and soymilk kefir in tumor bearing mice.
    Nutr Cancer 2002; 44(2): 183-7.
    18. Jain S, Yadav H, Sinha PR. Probiotic dahi containing Lactobacillus casei protects against Salmonella enteriti-
    dis infection and modulates immune response in mice. J Med Food 2009; 12(3): 576-83.
    19. Kawase M, He F, Kubota A, et al. Effect of fermented milk prepared with two probiotic strains on Japanese
    chedar pollinosis in a double-blind placebo-controlled clinical study. Int J Food Biol 2009; 128(3): 429-34.
    20. Diaz-Ropero MP, Martin R, Sierra S, et al. Two Lactobacillus strains isolated from breast milk differently mo-
    dulate the immune response J Appl Microbiol 2006; 102(2): 337-43.
    21. Tellez A, Corredig M, Brovko LY, Griffiths MS. Characterization of immune active peptides obtained from
    milk fermented by Lactobacillus helveticus. J Dairy Res 2010; 77(2): 129-36.
    22. Jain S, Yadav H, Sinha PR, et al. Modulation of cytokine gene expression in spleen and Peyer’s patches by
    feding dahi containing probiotic Lactobacillus casei in mice. J Digest Dis 2009; 10(1): 49-54.
    23. Elmadfa I, Klein P, Meyer AL. Immune-stimulating effects of lactic acid bacteria in vivo and in vitro. Proc
    Nutr Soc 2010; 69(3): 416-20.
    24. Meyer AL, Elmadfa I, Herbacek I, Micksche M. Probiotic, as well as conventional yogurt, can enhance the
    stimulated production of proinflammatory cytokines. J Hum Nutr Diet 2007; 20(6): 590-8.
    25. Hoppu U, Isolauri E, Laakso P, Matomaki J, Laitinen K. Probiotics and dietary counselling targeting mater-
    nal dietary fat intake modifies breast milk fatty acids and cytokines. Eur J Nutr 2012; 51(2): 211-9.
    26. Koyama T, Kirjavainen PV, Fisher C, et al. Development and pilot evaluation of a novel probiotic mixture
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    27. Kuitunen M, Kukkonen AK, Savilahti E. Impact of maternal allergy and use of probiotics during pregnancy
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    "La vera guida dei popoli sono le sue tradizioni. Senza tradizioni, vale a dire senza anima nazionale, non è possibile nessuna civiltà". Gustave Le Bon, Psicologia delle Folle [PDF GRATUITO]

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    Predefinito Re: Kefir ovvero l'Elisir di Lunga Vita

    Antitumor Effects
    Kefir also has significant antitumor activity against multiple cancer cell types. L. kefiri was shown to increase apoptosis of multiple drug resistant human myeloid leukemia cells in vitro through the activation of caspase 3 in a dose dependent manner (Ghoneum and Gimzewski, 2014). The cell free fraction of kefir has shown antitumor activity in vitro when it was observed to have a dose dependent anti-proliferative effect on the gastric cancer cell line SGC7901 (Gao et al., 2013). This study further demonstrated that cell free kefir was able to induce apoptosis in SGC7901 cells through up regulation of the bax gene, and apoptosis promoter and anti-oncogene, and down regulation of the bcl-2 gene, which is an apoptosis inhibitor and known oncogene (Sorenson, 2004). In addition to the promotion of cell death in cancerous cells, antimutagenic effects have been demonstrated in studies with known carcinogens such as methylmethanosulphate, methy-lazoxymethanol, sodium azide, aflatoxin B1, and 2-aminoanthracene as indicated by the Ames test (Guzel-Seydim et al., 2006).

    In mouse models of fusiform cell sarcomas, mice receiving intraperitoneal kefir had reduced tumor size, with some tumors completely disappearing over a 20 days treatment period (Cevikbas et al., 1994). While this is impressive, it has yet to be determined if these findings can be replicated in the case of oral consumption. A separate study utilizing a murine breast cancer model showed that kefir feeding prior to challenge with the tumor resulted in decreased size and increased apoptosis of the tumor, and that the levels of IgA+ cells and CD4+ T cells were also increased (de Moreno de LeBlanc et al., 2007). Mice with breast cancer tumors fed kefir also showed increased serum levels of Il-10 and IL-4 (de Moreno de LeBlanc et al., 2006). These studies both showed increases in immune cell populations and recruitment, pointing to a possible mechanism for the reduction of tumor size. These findings are consistent with other studies that have shown that kefir is able to modulate the immune system in the gut and show that the immunomodulatory abilities of kefir may not be limited to the gastrointestinal tract (Thoreux and Schmucker, 2001; Vinderola et al., 2005; Correa Franco et al., 2013).

    https://www.frontiersin.org/articles...016.00647/full
    "La vera guida dei popoli sono le sue tradizioni. Senza tradizioni, vale a dire senza anima nazionale, non è possibile nessuna civiltà". Gustave Le Bon, Psicologia delle Folle [PDF GRATUITO]

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    Predefinito Re: Kefir ovvero l'Elisir di Lunga Vita

    Antitumor activity of milk kefir and soy milk kefir in tumor-bearing mice.
    Liu JR1, Wang SY, Lin YY, Lin CW.
    Author information

    Abstract
    The effects of oral administration of milk and soy milk kefirs on tumor growth in tumor-bearing mice and the mucosal immunoglobulin A response in mice were studied. Oral administration of milk and soy milk kefirs to mice inoculated with sarcoma 180 tumor cells resulted in 64.8% and 70.9% inhibition of tumor growth, respectively, compared with controls. In addition, oral administration of the two kefir types induced apoptotic tumor cell lysis. Total immunoglobulin A levels for tissue extracts from the wall of the small intestine were also significantly higher for mice fed a milk kefir or a soy milk kefir regimen for 30 days. These results suggest that milk and soy milk kefirs may be considered among the more promising food components in terms of cancer prevention and enhancement of mucosal resistance to gastrointestinal infection.

    PMID: 12734066 DOI: 10.1207/S15327914NC4402_10
    [Indexed for MEDLINE]

    https://www.ncbi.nlm.nih.gov/pubmed/12734066
    https://www.tandfonline.com/doi/cite...27914NC4402_10
    "La vera guida dei popoli sono le sue tradizioni. Senza tradizioni, vale a dire senza anima nazionale, non è possibile nessuna civiltà". Gustave Le Bon, Psicologia delle Folle [PDF GRATUITO]

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    Predefinito Re: Kefir ovvero l'Elisir di Lunga Vita

    Il "siero di Bonifacio" d'altro canto era la risposta sbagliata al "perché le capre non hanno mai il cancro".



    MedBunker - Le scomode verità: Il siero di Bonifacio
    "La vera guida dei popoli sono le sue tradizioni. Senza tradizioni, vale a dire senza anima nazionale, non è possibile nessuna civiltà". Gustave Le Bon, Psicologia delle Folle [PDF GRATUITO]

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    Predefinito Re: Kefir ovvero l'Elisir di Lunga Vita

    Front Microbiol. 2019 Jan 11

    Elucidating the Immune-Related Mechanisms by Which Probiotic Strain Lactobacillus casei BL23 Displays Anti-tumoral Properties.
    Jacouton E1, Michel ML1, Torres-Maravilla E1, Chain F1, Langella P1, Bermúdez-Humarán LG1.

    Abstract
    We have recently described antitumor properties of Lactobacillus casei BL23 strain in both a mouse allograft model of human papilloma virus (HPV)-induced cancer and dimethylhydrazine-associated colorectal cancer. However, the mechanisms underlying these beneficial effects are still unknown. Interestingly, in vitro cellular models show that this bacterium is able to stimulate the production of high levels of IL-2. Because this cytokine has well-known antitumor properties, we decided to explore its role in the anti-cancer effects of BL23 using the HPV-induced cancer model. We found a negative correlation between IL-2 and tumor size confirming the necessity of IL-2 to protect from tumor development. Then, we blocked IL-2 synthesis using neutralizing monoclonal antibodies in mice that were challenged with lethal levels of tumor cells; this led to a significant reduction in the protective abilities of BL23. Next, we used a genetically modified strain of Lactococcus lactis to deliver exogenous IL-2 to the system, and in doing so, we were able to partially mimic the antitumor properties of BL23. Additionally, we showed the systemic role of T-cells in tumor protection through a negative correlation between tumor size and T-cells subpopulations and an increasement of BL23-specific local Foxp3 levels in tumor-bearing mice. Finally, we observed a negative correlation between tumor size and NK+ cells, but local recruitment of NK cells and cytotoxic activity appeared specific to BL23 treatment. Taken together, our data suggest that IL-2 signaling pathway plays an important role in the anti-tumoral effects of probiotic strain L. casei BL23. These results encourage further investigation in the use of probiotic strains for potential therapeutic applications to clinical practice, in particular for the treatment of colorectal cancer. Furthermore, our approach could be extended and applied to other potential beneficial microorganisms, such as gut microbiota, in order to better understand the crosstalk between microbes and the host.

    KEYWORDS:
    IL-2; Lactobacillus casei BL23; anti-tumor; cancer; probiotic

    PMID: 30687269 PMCID: PMC6336716 DOI: 10.3389/fmicb.2018.03281

    https://www.ncbi.nlm.nih.gov/pubmed/30687269
    "La vera guida dei popoli sono le sue tradizioni. Senza tradizioni, vale a dire senza anima nazionale, non è possibile nessuna civiltà". Gustave Le Bon, Psicologia delle Folle [PDF GRATUITO]

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    Predefinito Re: Kefir ovvero l'Elisir di Lunga Vita

    "La vera guida dei popoli sono le sue tradizioni. Senza tradizioni, vale a dire senza anima nazionale, non è possibile nessuna civiltà". Gustave Le Bon, Psicologia delle Folle [PDF GRATUITO]

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    Predefinito Re: Kefir ovvero l'Elisir di Lunga Vita

    "La vera guida dei popoli sono le sue tradizioni. Senza tradizioni, vale a dire senza anima nazionale, non è possibile nessuna civiltà". Gustave Le Bon, Psicologia delle Folle [PDF GRATUITO]

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    Predefinito Re: Kefir ovvero l'Elisir di Lunga Vita

    Trauma

    Travolta dal Viola del tramonto
    Taccio le mie Contusioni
    (Mary Ann)

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    Predefinito Re: Kefir ovvero l'Elisir di Lunga Vita

    Qualsiasi latte è merda da bere, non lo digeriamo.
    Venezuela e Zimbabwe nei nostri cuori!

 

 
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